Author

C. Sirac

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. Cogne· 4 shared S. Bender· 4 shared A. Bonaud· 3 shared M. V. Ayala· 3 shared A. Jaccard· 2 shared C. Carrion· 2 shared F. Bridoux· 2 shared L. Delpy· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersImmunology

M. Cogne

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival

C. Horiot, M. Roussel, A. Praite, J. Pollet, S. Bender, C. Sirac, A. Bonaud, L. Delpy

This study shows that antisense oligonucleotides targeting IgG mRNA reduce IgG secretion in myeloma cells, leading to toxic free-light chain accumulation and cell death.

bioRxiv · Aug 29, 2023 · PreprintImmunology

Single-hit genome edition for expression of single-chain immunoglobulins by edited B cells

N. Ueda, M. Cahen, c. sirac, A. Galy, J. Moreaux, Y. Danger, M. Cogne

This paper develops a method to redirect B cells to express single-chain immunoglobulins by editing a single genomic locus, validated in cell lines and primary B cells.

bioRxiv · Jun 2, 2022 · PreprintImmunology

New models to study plasma cells in mouse based on the restriction of IgJ expression to antibody secreting cells.

M. V. Ayala, A. Bonaud, S. Bender, J.-M. Lambert, F. Lechouane, C. Carrion, M. Cogne, V. Pascal, C. Sirac

The paper introduces two new mouse models, IgJGFP and IgJCreERT2, for studying plasma cells by leveraging IgJ expression as a marker for antibody-secreting cells.

bioRxiv · Aug 13, 2020 · PreprintImmunology

Full-length immunoglobulin high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome

S. Bender, V. Javaugue, A. Saintamand, M. V. Ayala, M. Alizadeh, M. Filloux, V. Pascal, N. Gachard, D. Lavergne, F. Auroy, M. Cogne, F. Bridoux, C. Sirac, A. Jaccard

This study uses high-throughput Ig repertoire sequencing to identify specific mutational patterns in POEMS syndrome, aiding in diagnosis and detection of low-abundance plasma cell clones.

bioRxiv · Oct 31, 2019Immunology

Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease

S. Bender, M. V. Ayala, A. Bonaud, V. Javaugue, C. Carrion, C. Oblet, A. Rinsant, N. Quellard, S. Kaaki, Z. Oruc, F. Boyer, A. Paquet, N. Pons, B. Herve, M. O. Ashi, , C. Sirac

This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.

bioRxiv · May 2, 2019 · PreprintPathology