BiophysicsbioRxivPreprint
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease
S. Günther, P. Y. A. Reinke, D. Oberthuer…·G
The paper presents the crystal structure of SARS-CoV-2 main protease covalently bound to a metabolite of HEAT, revealing a pro-drug mechanism and potential for non-peptidic inhibitors.
DOI 10.1101/2020.05.02.043554