A. Ramgopal

AMPK Drives Both Glycolytic and Oxidative Metabolism in T Cells During Graft-versus-host Disease

This study shows that AMPK drives both oxidative and glycolytic metabolism in T cells during GVHD, and its absence impairs metabolic flexibility and IFNγ production.

Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function

This study shows that overexpressing AMPKγ2 in human T cells enhances oxidative metabolism, improves expansion, and boosts function under low glucose conditions.