Expression of a recombinant high affinity IgG Fc receptor by engineered NK cells as a docking platform for therapeutic mAbs to target cancer cells
K. Snyder, R. Hullsiek, H. Mishra, D. Mendez, Y. Li, A. Rogich, D. Kaufman, J. Wu, B. Walcheck
This paper engineers NK cells with a recombinant Fc receptor to enhance ADCC and tumor targeting by avoiding ADAM17-mediated downregulation.
bioRxiv · Oct 2, 2018Immunology