Author

B. Walcheck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1

Frequent Co-Authors

J. Wu· 3 shared M. Felices· 3 shared B. R. Webber· 2 shared B. S. Moriarity· 2 shared E. J. Pomeroy· 2 shared J. S. Miller· 2 shared K. M. Snyder· 2 shared A. J. Lindstedt· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

J. Wu

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Author profile →

5 papers

Recent·Most cited

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells

A. W. Matson, R. H. Hullsiek, K. J. Dixon, A. J. Lindstedt, R. R. Friess, S. K. Phung, T. S. Freedman, M. Felices, E. N. Truckenbrod, J. Wu, J. Miller, B. Walcheck

This study shows that an ADAM17-blocking antibody enhances IL-15-mediated NK cell activation and proliferation through CD16A and CD137, with potential therapeutic applications in cancer.

bioRxiv · May 9, 2024Immunology

Ablation of SYK kinase from primary human Natural Killer cells via CRISPR/Cas9 enhances cytotoxicity and cytokine production

J. D. Dahlvang, J. K. Dick, J. A. Sangala, E. J. Pomeroy, K. M. Snyder, J. M. Moushon, C. E. Thefaine, J. Wu, S. E. Hamilton, M. Felices, J. S. Miller, B. Walcheck, B. R. Webber, B. S. Moriarity, G. T. Hart

This study ablates SYK kinase in primary human NK cells using CRISPR/Cas9, finding it enhances cytotoxicity and cytokine production compared to other gene ablations.

bioRxiv · May 29, 2022 · PreprintImmunology

Ectodomain shedding of L-selectin by ADAM17 in canine neutrophils

K. M. Snyder, C. McAloney, J. S. Montel, J. F. Modiano, B. Walcheck

This study shows ADAM17 mediates L-selectin shedding in canine neutrophils, which could be a therapeutic target for inflammation.

bioRxiv · Apr 6, 2020Immunology

Expression of a recombinant high affinity IgG Fc receptor by engineered NK cells as a docking platform for therapeutic mAbs to target cancer cells

K. Snyder, R. Hullsiek, H. Mishra, D. Mendez, Y. Li, A. Rogich, D. Kaufman, J. Wu, B. Walcheck

This paper engineers NK cells with a recombinant Fc receptor to enhance ADCC and tumor targeting by avoiding ADAM17-mediated downregulation.

bioRxiv · Oct 2, 2018Immunology

A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

E. J. Pomeroy, J. T. Hunzeker, M. T. Kluesner, M. R. Crosby, W. S. Lahr, L. Bendzick, J. S. Miller, B. R. Webber, M. A. Geller, B. Walcheck, M. Felices, T. K. Starr, B. S. Moriarity

This paper develops a CRISPR/Cas9-based method to edit human NK cells, enhancing their anti-cancer activity by knocking out ADAM17 and PD1.

bioRxiv · Sep 29, 2018Immunology