Direct observation of ATP-driven ubiquitin chain handling by Cdc48
Dhawal Choudhary, Jack Robert Tait, Matthias Kracht, A. Roland, Johannes van den Boom, V. Sunderlíková, Hemmo H Meyer, Sander J. Tans
This study directly observes ATP-driven ubiquitin chain handling by Cdc48, revealing non-processive and processive modes of action and their role in ubiquitin unfolding and chain selection.
Nature Communications · May 4, 2026Peer-reviewedBiophysics