T. Kim

Inhibiting monocyte migration reduces arterial thrombosis and facilitates thrombolysis

This study shows that inhibiting monocyte migration via CCR2 deficiency reduces arterial thrombosis and improves thrombolysis in mice.

Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants

This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.

Phospho-KNL-1 recognition by a TPR domain targets the BUB-1/BUB-3 complex to C. elegans kinetochores

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

Spatial dissection of cellular heterogeneity and functional crosstalk in the tumor microenvironments of gastric cancers

This study uses spatial transcriptomics to analyze gastric cancer tumor microenvironments, identifying subtypes and functional interactions between cell types that correlate with clinical outcomes.

Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

The paper identifies FYN and KDM4 as synergistic targets for enhancing TKI efficacy in triple negative breast cancer through CRISPR screens and mechanistic analysis.

Phage-mediated resolution of genetic conflict alters the evolutionary trajectory of Pseudomonas aeruginosa lysogens

This study shows that phage-mediated resolution of genetic conflict in Pseudomonas aeruginosa lysogens leads to evolutionary changes in CRISPR immunity and genome structure.

Intra-ocular Predation of Fluoroquinolone-Resistant Pseudomonas aeruginosa and Serratia marcescens by Predatory Bacteria

This study evaluates the ability of predatory bacteria to limit intraocular growth of resistant Gram-negative bacteria in a rabbit model, finding that active predation, not antimicrobial effects, is responsible for inhibiting Pseudomonas aeruginosa.

Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

The paper shows selenium reduces ubiquinone to ubiquinol via SQOR, protecting against ferroptosis independently of selenoprotein production.

Predatory Bacteria can Reduce Pseudomonas aeruginosa Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model

Deep spatial-omics to aid personalization of precision medicine in metastatic recurrent Head & Neck Cancers

This study uses spatial-omics to identify tumor metabolic states and immune cell profiles in OPSCC, leading to insights on ICI failure and potential drug targets.

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.

PLK-1 tethered on BUB-1 directs CDC-20 kinetochore recruitment to ensure timelyembryonic mitoses

This study shows that PLK-1 tethered on BUB-1 promotes CDC-20 recruitment to kinetochores, ensuring timely mitosis in C. elegans embryos through phosphoregulation.

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

Decoding Imagined Musical Pitch from Human Scalp Electroencephalograms

This study decodes imagined musical pitch from human scalp EEG, achieving 35.68% accuracy using SVM and showing similar performance with DC features across different class numbers.

Rebound Excitation of Epileptiform Activities by Transcranial Focused Ultrasound Stimulation

This study shows that transcranial focused ultrasound can induce both suppressive and excitatory responses in an epilepsy model, depending on stimulation parameters.

Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

This study compares the infectivity of SARS-CoV-2 variants in human alveolar cells, finding Omicron (BA.1) to be 3-5-fold more infectious than other variants at early infection.

Thermal Effects on Neurons During Stimulation of the Brain

This study examines thermal effects on neurons during brain stimulation, finding that temperature changes induce transient suppression and excitation through ion fluxes and bifurcation dynamics.

A Low-Dose Triple Antibody Cocktail Against the Ectodomain of the Matrix Protein 2 of Influenza A Is A Universally Effective and Viral Escape Mutant Resistant Therapeutic Agent

This paper develops a low-dose triple antibody cocktail targeting the conserved M2e antigen of influenza A, showing universal efficacy and resistance to viral escape mutants in mouse models.

Probing stress-regulated ordering of the plant cortical microtubule array via a computational approach

This paper develops a computational model to simulate how mechanical stress influences cortical microtubule orientation and organization in plant cells, revealing key parameters that mediate stress-dependent patterning.

Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

This study shows that boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibodies and protection against B.1.1.529 in mice, with the Omicron-matched booster showing slightly better outcomes.

Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

The paper measures microtubule growth dynamics using interference reflection microscopy and models the effects of GTP hydrolysis, revealing that GDP exposure at the microtubule end increases growth fluctuations and suggests slow association kinetics.

Mechanical Compression Creates a Quiescent Muscle Stem Cell Niche

This study shows that mechanical compression of muscle stem cells induces quiescence by altering tension and activating Notch signaling independently of canonical cleavage.

A genome-wide genetic screen uncovers novel determinants of human pigmentation

A genome-wide CRISPR-Cas9 screen identifies novel genes regulating melanogenesis, many upregulated in dark skin melanocytes and associated with skin color variation.

Interrogation of the integrated mobile genetic elements in gut-associated Bacteroidaceae with a consensus prediction approach

The paper introduces VICSIN, a consensus method for predicting and clustering mobile genetic elements in gut-associated Bacteroidaceae, identifying novel MGEs and revealing gene sharing patterns.

TRIB1 regulates tumour growth via controlling tumour-associated macrophage phenotypes and is associated with breast cancer survival and treatment response

This paper shows TRIB1 in macrophages affects breast cancer growth and treatment response by altering cytokine levels and immune cell composition.

Antiviral effect of a nucleic acid hydrolyzing scFv against oseltamivir resistant influenza A virus

This study demonstrates that 3D8 scFv has antiviral activity against oseltamivir-resistant influenza A virus in cell and mouse models.

Rapid assembly of a polar network architecture drives efficient actomyosin contractility

This paper investigates how RhoA-driven actomyosin contractility in C. elegans embryos is mediated by formin dynamics and polar actin network assembly, showing that barbed-end saturation and network polarity enhance contractility efficiency.

CTCF-mediated Genomic Effects of BART Region on Epstein-Barr Virus Chromatin 3D Structure in Gastric Carcinoma Cells

This study investigates how CTCF binding at the BARTp site regulates EBV 3D genome structure and gene expression in EBVaGC cells, showing its role in DNA looping and viral infectivity.

The nature of mitotic forces in epithelial monolayers

This study identifies two distinct stages of mitotic force generation in epithelial monolayers: protrusive forces driving mitotic elongation and outward forces facilitating post-mitotic re-spreading.