Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries
S. A. Misek, A. Fultineer, J. Kalfon, J. Noorbakhsh, I. Boyle, J. Dempster, L. Petronio, K. Huang, A. Saadat, T. Green, A. Brown, J. G. Doench, D. E. Root, J. McFarland, R. Beroukhim, J. S. Boehm
The paper identifies ancestry-related biases in CRISPR experiments caused by germline variants, showing disproportionate effects in cell models from recent African descent.
Nature Communications · Jun 7, 2024Peer-reviewedCancer Biology