K. Huang

XPOT Deficiency causes a human disorder through impaired tRNA nuclear export

This study identifies XPOT deficiency as a human disorder causing immune defects, hearing loss, and developmental issues through impaired tRNA nuclear export.

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

The paper identifies ancestry-related biases in CRISPR experiments caused by germline variants, showing disproportionate effects in cell models from recent African descent.

Flow zoometry of Drosophila

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

The structure and diversity of the bacterial community in the overlying water of the Yangzong Lake in Yunnan

This study analyzes bacterial community structure and diversity in Yangzong Lake overlying water using high-throughput sequencing, finding variations in physicochemical factors and dominant taxa across sampling sites.

Challenges in quantifying functional redundancy and selection in microbial communities

The paper challenges the assumption that reduced functional variability in microbial communities indicates selection, showing that apparent functional selection can be artifacts of statistical averaging and functional bias.

Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish

This study shows that zebrafish Naa80 acetylates actins and is essential for normal hearing, but not for muscle development or viability.

Scaling laws of molecular residence time

The paper reveals power law residence scaling in both passive and active liquids, showing sensitivity to liquid environment and suggesting active phase separation as a scaling proofreading mechanism in gene regulation.

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

A continental-scale analysis reveals the latitudinal gradient of stomatal density across amphistomatous species: Evolutionary history vs. present-day environment

The paper analyzes stomatal density across amphistomatous plant species in China, finding that evolutionary history explains more variation than environmental factors.

A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex

The paper reports a cryo-EM structure of the KTF1-bound Pol V transcription elongation complex, revealing structural features that explain its unique transcriptional properties and role in DNA methylation.

Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation

This study uses patient-derived iPSC-CMs to show that a titin truncating variant increases arrhythmia susceptibility and disrupts sarcomere structure in both atrial and ventricular tissues.

Mechanism of outer membrane destabilization by global reduction of protein content

This study investigates how reducing outer membrane protein content in Gram-negative bacteria weakens the outer membrane, alters cell shape, and causes rupture by disrupting lipid asymmetry.

Defining the structure, signals, and cellular elements of the gastric mesenchymal niche

The paper identifies regional subpopulations and niche properties of gastric PDGFRA+ mesenchymal cells, revealing distinct roles in supporting corpus and antral organoids.

Assembly of gut-derived bacterial communities follows "early-bird" resource utilization dynamics

This study shows that gut microbiota assembly follows 'early-bird' dynamics where fast-growing species dominate nutrient sources, and develops a predictive model for community composition based on nutrient inputs.

Spatial Localization Ability of Planarians Identified Through the Light Maze Paradigm

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

Rapid, automated and experimenter-free assessment of cognitive flexibility reveals learning impairments following recovery from activity-based anorexia in female rats

This study develops an automated cognitive testing system for rats and finds that cognitive inflexibility does not predispose to anorexia but is linked to weight loss resistance after recovery.

Phase separation as high-order catalyst

The paper proposes a model where phase separation of regulatory elements acts as a catalyst for chromatin-mediated reactions by lowering activation barriers and stabilizing transition states.

Re-evaluating homoploid reticulate evolution in the annual sunflowers.

This study re-evaluates homoploid reticulate evolution in annual sunflowers using whole genome resequencing, finding widespread admixture and ancient hybridization events across the genus.

Intermittent hypoxia therapy engages multiple longevity pathways to double lifespan in C.elegans

This study shows intermittent hypoxia therapy doubles C. elegans lifespan without HIF-1 but requires DAF-16/FOXO and other phosphatidylinositol signaling components.

Diving Behavior Reveals Humidity Sensing Ability of Water Deprived Planarians

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal LRR motif for binding interaction partners

This study reports the crystal structure of the N-terminal domain of CFAP410 and shows how mutations in this domain disrupt its structural stability and interaction with partners, leading to disease.

Antibiotic effects on microbial communities are modulated by resource competition

This study shows how resource competition affects microbial community diversity in response to antibiotics, revealing non-monotonic richness changes and non-transitive/non-additive effects.

Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness

The paper identifies a DPP4 homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness, showing it is inhibited by diabetes drugs.

Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-COV-2 Delta Variant

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device

The paper develops an ingestible device to collect intestinal samples and identifies regional differences in microbiota and bile acids compared to stool.

M-TUBE: a fabrication-free microfluidic device for large-volume bacterial electroporation requiring minimal assembly

The paper introduces a microfluidic device for large-volume bacterial electroporation that outperforms conventional cuvettes and generates a transposon mutant library in Bifidobacterium longum.

Systematic analysis of human antibody response to ebolavirus glycoprotein reveals high prevalence of neutralizing public clonotypes

The paper analyzes the human antibody response to ebolavirus glycoprotein, identifying public clonotypes with neutralizing activity and implications for vaccine design.

High homozygosity of inversions in sunflower species largely averts accumulation of deleterious mutations

This study examines recombination, transposable elements, and deleterious mutations in sunflower species, finding that inversion homozygosity reduces mutation accumulation.

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.