Insight into glycosphingolipid crypticity: Crystal structure of the anti-tumor antibody 14F7 and recognition of NeuGc GM3 ganglioside
K. Bjerregaard-Andersen, H. Johannesen, F. Abraha, A. Sakanovic, D. Grosser, U. Coskun, G. Anderluh, S. Oscarson, E. Moreno, M. Grzybek, U. Krengel
This paper presents the crystal structure of the 14F7 antibody bound to NeuGc GM3 and shows how membrane composition and curvature influence its binding.
bioRxiv · Sep 18, 2020Biochemistry