Author

U. Coskun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 2 Biophysics· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:metabolomics· 3 Research Focus:protein structure prediction· 3

Frequent Co-Authors

M. Grzybek· 6 shared A. Palladini· 4 shared T. Chavakis· 3 shared B. Wielockx· 2 shared J. Guck· 2 shared P. Sala· 2 shared T. Gutmann· 2 shared V. I. Alexaki· 2 shared

Activity by Year

2017-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersBiochemistry

M. Grzybek

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Insight into glycosphingolipid crypticity: Crystal structure of the anti-tumor antibody 14F7 and recognition of NeuGc GM3 ganglioside

K. Bjerregaard-Andersen, H. Johannesen, F. Abraha, A. Sakanovic, D. Grosser, U. Coskun, G. Anderluh, S. Oscarson, E. Moreno, M. Grzybek, U. Krengel

This paper presents the crystal structure of the 14F7 antibody bound to NeuGc GM3 and shows how membrane composition and curvature influence its binding.

bioRxiv · Sep 18, 2020Biochemistry

Obesity-associated lipidomic remodeling of the adrenal gland indicates an important role of the FADS2-arachidonic acid axis in adrenocortical hormone production

A. Witt, P. Mirtschink, A. Palladini, I. Mateska, H. Abdelmegeed, M. Grzybek, B. Wielockx, M. Peitzsch, U. Coskun, T. Chavakis, V. I. Alexaki

This study identifies obesity-induced lipidomic changes in the adrenal gland, showing that the FADS2-arachidonic acid pathway regulates adrenocortical hormone production.

bioRxiv · Sep 4, 2020 · PreprintCell Biology

HIF2α is a Direct Regulator of Neutrophil Motility

S. Sormendi, M. Deygas, A. Sinha, A. Krueger, I. Kourtzelis, G. Le Lay, M. Bernard, P. Saez, M. Gerlach, K. Franke, A. Meneses, M. Kraeter, A. Palladini, J. Guck, U. Coskun, , B. Wielockx

This study identifies HIF2α as a regulator of neutrophil motility through the PHD2-HIF2-RhoA axis, enhancing migration in hypoxic environments during inflammation.

bioRxiv · Jun 5, 2020Immunology

Purification of age-distinct insulin secretory granules through antigen restriction

M. Neukam, P. Sala, A.-D. Brunner, K. Ganss, A. Palladini, M. Grzybek, J. Vasiljevic, J. Broichhagen, U. Coskun, K. Johnsson, T. Kurth, M. Mann, M. Solimena

The paper purifies age-distinct insulin secretory granules from INS-1 cells and identifies age-related changes in their lipid composition and membrane properties.

bioRxiv · Jun 3, 2020Cell Biology

Addressing lipid structural diversity in signalling: Photochemical probes for live-cell lipid biochemistry

M. Schuhmacher, A. T. Grasskamp, N. Wagner, B. Lombardot, J. S. Schuhmacher, P. Sala, A. Lohmann, I. Henry, A. Shevchenko, U. Coskun, A. M. Walter, A. Nadler

This study develops photochemical probes to manipulate diacylglycerol species in live cells, revealing structural diversity impacts on protein binding and signaling.

bioRxiv · Jul 22, 2019Biochemistry

Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain

T. Gutmann, I. Schaefer, C. Poojari, B. Brankatschk, I. Vattulainen, M. Strauss, U. Coskun

The paper reports the cryo-EM structure of the insulin receptor ectodomain with four insulin molecules, revealing two binding sites and a T-shaped conformation.

bioRxiv · Jun 21, 2019Biochemistry

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

M. Grzybek, A. Palladini, V. I. Alexaki, M. A. Surma, K. Simons, T. Chavakis, C. Klose, U. Coskun

This paper presents a validated shotgun lipidomics method for adipose tissue, revealing diet-related lipidomic differences in brown, gonadal, and inguinal subcutaneous fat from lean and obese mice.

bioRxiv · Nov 14, 2018 · PreprintPhysiology

Visualization of ligand-induced transmembrane signalling in the full-length human insulin receptor

T. Gutmann, K. H. Kim, M. Grzybek, T. Walz, U. Coskun

The paper visualizes how insulin binding changes the structure of the human insulin receptor, leading to autophosphorylation.

bioRxiv · Oct 23, 2017Biochemistry

Detection Of Human Disease Conditions By Single-Cell Morpho-Rheological Phenotyping Of Whole Blood

N. Toepfner, C. Herold, O. Otto, P. Rosendahl, A. Jacobi, M. Krater, J. Stachele, L. Menschner, M. Herbig, L. Ciuffreda, L. Ranford-Cartwright, M. Grzybek, U. Coskun, E. Reithuber, G. Garriss, , J. Guck

This paper introduces a method to detect human disease conditions by analyzing whole blood using morpho-rheological phenotyping without labeling or separation.

bioRxiv · Jun 1, 2017Biophysics