Enhancer Remodeling Promotes Tumor-Initiating Activity in NRF2-Activated Non-Small Cell Lung Cancers
K. Okazaki, H. Anzawa, Z. Liu, N. Ota, H. Kitamura, Y. Onodera, M. M. Alam, D. Matsumaru, T. Suzuki, F. Katsuoka, S. Tadaka, I. Motoike, M. Watanabe, A. Sakurada, Y. Okada, , H. Motohashi
The paper identifies NRF2-CEBPB cooperativity in promoting tumor-initiating activity in NRF2-activated NSCLCs through enhancer remodeling and the NRF2-NOTCH3 regulatory axis.
bioRxiv · Apr 24, 2020Cancer Biology