Acute myeloid leukemia mitochondria hydrolyze ATP to resist chemotherapy
J. T. Hagen, M. Montgomery, R. Aruleba, B. Chrest, T. D. Green, M. Kassai, T. Zeczycki, C. A. Schmidt, D. Bhowmick, S.-F. Tan, D. Feith, C. Chalfant, T. Loughran, D. Liles, M. Minden, , K. Fisher-Wellman
This study identifies a bioenergetic mechanism in AML cells where mitochondria consume ATP to resist chemotherapy, offering a target for improving treatment.
bioRxiv · Apr 12, 2024 · PreprintCancer Biology