A. Sinha

Stretching the structural envelope of isomeric imatinib analogs that reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP

The paper investigates how structurally diverse imatinib analogs affect APP metabolism similarly, identifying potent isomers for further development.

Redox-driven control of Yuh1/UCHL3 impacts mitochondrial health via NEDD8/Rub1 pathway

The paper investigates how redox changes affect Yuh1/UCHL3 activity, revealing a thiol-based redox switch that modulates NEDD8/Rub1 processing and impacts mitochondrial health.

Centromeric localization of KNL2 and CENP-C proteins in plants depends on their centromere-targeting domain and DNA-binding regions

Structure and Functions of Gesture Sequences in Wild Bonnet Macaques (Macaca radiata)

This study examines gesture sequences in wild bonnet macaques, finding non-random combinations and specific functions, suggesting potential evolutionary links to human language.

Niche exclusion of a lung pathogen in mice with designed probiotic communities

This study shows that probiotic communities can prevent Burkholderia thailandensis infection in mice by reducing niche overlap with the pathogen.

A pipeline for facile cloning of antibody Fv domains and their expression, purification, and characterization as recombinant His-tagged IgGs

Elephants in a teacup: Ranging and Habitat-use of Asian elephants Elephas maximus in a Plantation Dominated Landscape in Southern Western Ghats, India

This study tracks four Asian elephant herds over five years in a plantation-dominated landscape, finding minimal spatial overlap and increased use of natural vegetation, highlighting the need for conservation strategies beyond protected areas.

Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers

The paper identifies prognostically relevant co-expression patterns between coding and noncoding RNAs in HPV16-positive cervical cancers and links them to patient survival.

Evolution of tandem repeats in putative CSP to enhance its function: A recent and exclusive event in Plasmodium vivax in India

The paper identifies genetic polymorphism and natural selection in PvpuCSP of Plasmodium vivax, highlighting its role in adaptation and diversity.

ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression

This study identifies ACSL4 as a driver of TNBC metastasis by enhancing histone acetylation and SNAIL expression through metabolic and epigenetic mechanisms.

Rational development of a small-molecule activator of CK1γ2 that decreases C99 and beta-amyloid levels

This study identifies CK1γ2 as a therapeutic target for Alzheimer's disease by showing its activation reduces C99 and beta-amyloid levels through increased PS1-Ser367 phosphorylation.

PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)

This study shows that PERK inhibition reduces SLC7A11 expression and sensitizes colon cancer cells to ferroptosis, suggesting PERK inhibitors as potential therapeutics.

CD38 promotes hematopoietic stem cell dormancy via c-Fos

This study identifies CD38 as a marker for dormant hematopoietic stem cells and shows it promotes dormancy through the cADPR/Ca2+/c-Fos/p57Kip2 pathway.

Niche partitioning and coexistence of sympatric macaques in a fragmented habitat of the Upper Brahmaputra Valley, northeastern India

This study examines how three sympatric macaque species partition resources in a fragmented rainforest, finding that spatial and dietary niche differentiation enables their coexistence.

Possible Self-awareness in Wild Adelie Penguins Pygoscelis adeliae

This study investigates self-awareness in wild Adelie penguins using mirror tests in their natural environment, suggesting potential self-recognition and social awareness.

An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

The paper identifies an RNA modification enzyme in Enterococcus faecalis that senses reactive oxygen species and regulates translation of stress-response proteins.

Female Friendships: Social Network Analysis as a tool to understand intra-group affiliation in semi-commensal lion-tailed macaques (Macaca silenus)

This study uses social network analysis to examine how varying degrees of human habituation affect intra-group affiliative relationships in lion-tailed macaques, finding differences in connection patterns between dominant and subordinate individuals.

Ranging patterns of the rainforest-adapted lion-tailed macaque Macaca silenus in a human-dominated landscape in the Anamalai hills of the Western Ghats, India

This study examines the ranging patterns of lion-tailed macaques in a human-dominated landscape, finding increased reliance on anthropogenic food and associated threats.

Gemini calling! First occurrence of successful twinning in wild, endangered lion-tailed macaques Macaca silenus in the Anamalai hills of the Western Ghats, India

The paper reports the first successful twinning in wild lion-tailed macaques, linking survival to maternal behavior and provisioning.

A Multifunctional Anchor for Multimodal Expansion Microscopy

This paper introduces a multifunctional anchor for expansion microscopy, enabling simultaneous imaging of multiple biomolecules with reduced cost and complexity.

Succinate mediates inflammation-induced adrenocortical dysfunction

This study identifies the IL-1β-DNMT1-SDHB-succinate axis as a mechanism by which inflammation impairs adrenal steroidogenesis.

Generating an in vitro gut model with physiologically relevant biophysical mucus properties

This study creates an in vitro gut model with mucus properties similar to porcine tissue, using Caco-2 and HT29-MTX cells, and shows how cell ratios affect mucus biophysical characteristics.

Demographic changes of a tropical understory bird in naturally patchy montane habitats in southern India

This study examines how patch size and disturbance affect demographic parameters of a threatened understory bird in the Western Ghats, finding that survival decreases with disturbance but not patch size.

Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates severity of DSS-colitis

This study shows that transplanting bacteriophages from UC patients alters gut bacteria and worsens colitis in mice.

Bone Marrow-Derived AXL Tyrosine Kinase Promotes Mitogenic Crosstalk and Cardiac Allograft Vasculopathy

This study shows that bone marrow-derived AXL tyrosine kinase promotes cardiac allograft vasculopathy by enhancing immune cell accumulation and vascular smooth muscle cell proliferation.

H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis

This study shows that H3K27me3 promotes TNBC peritoneal metastasis by upregulating KRT14 through repression of Sp1, and suggests tazemetostat as a potential therapeutic target.

Immunogenic Potential of DNA Vaccine candidate, ZyCoV-D against SARS-CoV-2 in Animal Models

This study evaluates the immunogenic potential of the DNA vaccine ZyCoV-D against SARS-CoV-2 in animal models, showing antibody and Th-1 responses.

Classical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer

This study identifies distinct lineage states in small cell lung cancer driven by c-Myc and L-Myc, showing their unique roles in molecular subtypes and histology.

Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier

This paper shows that a single amino acid swap at position 72 can switch the substrate specificity of Rub1/NEDD8 and ubiquitin, revealing their distinct roles in cellular modification pathways.

HIF2α is a Direct Regulator of Neutrophil Motility

This study identifies HIF2α as a regulator of neutrophil motility through the PHD2-HIF2-RhoA axis, enhancing migration in hypoxic environments during inflammation.