Author

K. Aliar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

R. Khokha· 5 shared F. Vyas· 4 shared B. T. Grünwald· 2 shared B. Zhang· 2 shared C. W. McCloskey· 2 shared N. Chan· 2 shared N. Krebs· 2 shared P. Bronsert· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersCancer Biology

R. Khokha

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

FABP7 Progenitors are a Targetable Metabolic Root in the BRCA1 Breast

C. W. McCloskey, B. Zhang, M. Waas, G. Abazari, F. Vyas, K. Aliar, P. Tharmapalan, A. Kuttanamkuzhi, S. Narala, J. Cruikshank, S. O. P. Hofer, H. W. Jackson, T. Kislinger, H. K. Berman, R. Khokha

This study identifies FABP7 progenitors as a targetable metabolic root in BRCA1 breast cancer, showing their dysregulation and potential inhibition via fatty acid metabolism disruption.

bioRxiv · Nov 2, 2023 · PreprintCell Biology

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

L. Klein, M. Tu, N. Krebs, L. Urbach, D. G. Grimm, M. U. Latif, F. Penz, N. Chan, K. Aliar, F. Vyas, U. Kishore, E. Hessmann, A. Trumpp, E. Espinet, A. Papantonis, , S. K. Singh

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

bioRxiv · Oct 30, 2023 · PreprintCancer Biology

Hourglass, a tool to mine bioimaging data, uncovers sex-disparities in the IL-6-associated T cell response in pancreatic tumors

K. Aliar, H. R. Waterhouse, F. Vyas, N. Krebs, E. Poulton, B. Zhang, N. Chan, P. Bronsert, S. E. Fischer, S. Gallinger, B. T. Grünwald, R. Khokha

Hourglass processes bioimaging data to reveal sex-specific IL-6 effects on T cell responses in pancreatic tumors.

bioRxiv · Sep 12, 2022 · PreprintCancer Biology

Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

B. T. Grünwald, A. Devisme, G. Andrieux, F. Vyas, K. Aliar, C. W. McCloskey, A. Macklin, G. H. Jang, R. Denroche, J. M. Romero, P. Bavi, P. Bronsert, F. Notta, G. O'Kane, J. Wilson, , R. Khokha

This study identifies spatially confined sub-tumor microenvironments in PDAC that drive distinct tumor progression outcomes.

bioRxiv · Feb 18, 2021Cancer Biology

Mammary epithelial cells have lineage-restricted metabolic identities

M. Mahendralingam, K. Aliar, A. E. Casey, D. Pellacani, H. Kim, V. Ignatchenko, M. G. Valero, L. Palomero, A. Sinha, V. Stambolic, M. Alam, A. Schimmer, H. Berman, M. A. Pujana, C. J. Eaves, , R. Khokha

The paper identifies lineage-restricted metabolic identities in normal mammary epithelial cells and links them to breast cancer metabolic heterogeneity.

bioRxiv · Oct 8, 2019Cell Biology