Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activation
Z. ZHANG, L. RAN, R. Venditti, Z. Liu, A. Schurmann, J. S. Bonifacino, M. A. De Matteis, R. RICCI
This study shows that defective endosome-TGN retrograde transport enhances NLRP3 inflammasome activation in macrophages, leading to increased inflammation and susceptibility to sepsis.
bioRxiv · Sep 14, 2021 · PreprintImmunology