Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1
A. Schwarzer, M. Oliveira, M.-J. Kleppa, S. D. Slattery, A. Anantha, A. Cooper, M. Hannink, A. Schambach, A. Dorrie, A. Kotlyarov, M. Gaestel, T. Hembrough, J. Levine, M. Luther, M. Stocum, , M. J. Kostura
This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.
bioRxiv · Jun 12, 2022Cancer Biology