A. Cooper

Intercellular Communication via Mitotic Nanotubes is Influenced by Connexin-43 Trafficking and Actin Remodeling

This study shows that mitotic nanotubes, influenced by Cx43 trafficking and actin remodeling, enable reduced gap junction communication during cell division.

Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention

This paper identifies mCMQ069, a novel antimalarial with potential for single-dose cure and one-month chemoprevention, showing improved pharmacokinetic properties over KAF156.

Murine trypanosomiasis recapitulates transcriptomic features of acute kidney injury

This study shows that Trypanosoma brucei infection in mice causes kidney injury with transcriptomic features similar to acute kidney injury.

Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.

HSV-1 ICP0 Dimer Domain Adopts a Novel β-barrel Fold

This study determines the structure of the HSV-1 ICP0 dimer domain, revealing a novel β-barrel fold and its interactions with SUMO1.

Ultrahigh yields of giant vesicles obtained through mesophase evolution and breakup

This paper discovers a new pathway for forming giant unilamellar vesicles (GUVs) with ultrahigh yields (>50%) using a lipid-dense mesophase and fluid shear.

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

Methods to Utilize Pulse Wave Velocity to Measure Alterations in Cerebral and Cardiovascular Parameters

This paper presents methods to measure impedance-based pulse wave velocity in systemic and cerebral vascular systems to study cardiovascular and cerebral parameters in Alzheimer's disease models.

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

Spatially-resolved single cell transcriptomics reveal a critical role for γδ T cells in the control of skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection

This study uses spatial and single-cell transcriptomics to show that γδ T cells and adipocytes collaborate to control skin inflammation and adipose tissue wasting during chronic Trypanosoma brucei infection.

FLAgellum Member 8 modulates extravascular distribution of African trypanosomes.

This paper identifies FLAM8 as a flagellar protein that modulates extravascular dissemination of Trypanosoma brucei in mammalian hosts, without affecting transmissible stage differentiation.

Osmotic pressure enables high yield assembly of giant vesicles in solutions of physiological ionic strengths

This study investigates how osmotic pressure from polymers enhances GUV assembly in salty solutions, showing that low gelling temperature agarose achieves over 10% yield.

IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection

Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1

This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.

Broadly neutralizing antibodies target the coronavirus fusion peptide

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

An age-depth model and revised stratigraphy of vertebrate-bearing units in Natural Trap Cave, Wyoming

This study establishes a revised stratigraphy and age-depth model for Natural Trap Cave, revealing discontinuous sedimentation and reworking, and refuting a prominent snow cone's role in sediment distribution.

Ancient genomes reveal hybridisation between extinct short-faced bears and the extant spectacled bear (Tremarctos ornatus)

The paper uses ancient nuclear genome sequences to show that the extant spectacled bear has ancestry from Pleistocene hybridization with an extinct short-faced bear lineage, causing discordance between mitochondrial and nuclear phylogenies.

Lions and brown bears colonized North America in multiple synchronous waves of dispersal across the Bering Land Bridge

This study analyzes mitochondrial genomes of ancient brown bears and lions to show synchronous dispersal and extinction events across the Bering Land Bridge during the Pleistocene.

Introgression, hominin dispersal and megafaunal survival in Late Pleistocene Island Southeast Asia

The paper investigates introgression and hominin dispersal in Island Southeast Asia, finding widespread Denisovan ancestry but no evidence of super-archaic hominin admixture.

Role of SpoIVA ATPase Motifs During Clostridioides difficile Sporulation

This study investigates how ATPase motifs in SpoIVA affect spore formation in C. difficile, showing that SipL recognizes the ATP-bound form of SpoIVA for proper coat assembly.

Untangling the Evolutionary History of European Bison (Bison bonasus)

This study analyzes ancient mitochondrial genomes of European bison to reveal population dynamics and environmental adaptations over 50,000 years.

Laboratory contamination over time during low-biomass sample analysis

This study examines laboratory contamination in low-biomass samples over time, finding that contaminants vary by lab, season, and extraction method, and recommends controls and reporting to mitigate their impact.

Biological and cultural drivers of oral microbiota in Medieval and Post-Medieval London, UK

This study analyzes ancient dental calculus from Medieval and Post-Medieval London to link microbiota diversity with cultural, environmental, and health factors.