Author

L. Stiles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:metabolism & bioenergetics· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:metabolomics· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

O. S. Shirihai· 3 shared A. E. Jones· 2 shared A. S. Divakaruni· 2 shared A. A. Elorza· 1 shared A. Acevedo· 1 shared A. Anantha· 1 shared A. B. Ball· 1 shared A. Cooper· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

O. S. Shirihai

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

A. Acevedo, A. E. Jones, B. T. Danna, R. Turner, K. P. Montales, C. Beninca, K. Reue, O. S. Shirihai, L. Stiles, M. Wallace, Y. Wang, A. M. Bertholet, A. S. Divakaruni

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

bioRxiv · Aug 15, 2023 · PreprintBiochemistry

Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA

K. E. Heyden, J. L. Fiddler, Y. Xiu, O. V. Malysheva, M. K. Handzlik, W. N. Phinney, L. Stiles, S. S. Stabler, C. Metallo, M. A. Caudill, M. S. Field

This study shows that reduced Mtr expression causes B12 deficiency, leading to uracil accumulation in mtDNA and impaired mitochondrial function in mice.

bioRxiv · Aug 29, 2022 · PreprintBiochemistry

Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1

A. Schwarzer, M. Oliveira, M.-J. Kleppa, S. D. Slattery, A. Anantha, A. Cooper, M. Hannink, A. Schambach, A. Dorrie, A. Kotlyarov, M. Gaestel, T. Hembrough, J. Levine, M. Luther, M. Stocum, , M. J. Kostura

This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.

bioRxiv · Jun 12, 2022Cancer Biology

Calculation of ATP production rates using the Seahorse XF Analyzer

B. R. Desousa, K. K. O. Kim, A. E. Jones, A. B. Ball, W. Y. Hsieh, P. Swain, D. H. Morrow, D. A. Ferrick, A. J. Brownstein, O. S. Shirihai, A. Neilson, D. A. Nathanson, G. W. Rogers, B. P. Dranka, A. N. Murphy, , A. S. Divakaruni

The paper develops a method to calculate ATP production rates from oxidative phosphorylation and glycolysis using Seahorse XF Analyzer data, enabling direct comparison of ATP sources in live cells.

bioRxiv · Apr 16, 2022Biochemistry

Exacerbation of mitochondrial fission in human CD34+ cells halts erythropoiesis and hemoglobin biosynthesis

A. M. Gonzalez, L. M. Ruiz, E. L. Jensen, C. A. Echeverria, V. Romero, L. Stiles, O. S. Shirihai, A. A. Elorza

This study shows that excessive mitochondrial fission in human CD34+ cells disrupts erythropoiesis and hemoglobin biosynthesis by altering mitochondrial morphology and function.

bioRxiv · Jul 31, 2020 · PreprintCell Biology