Author

A. Schambach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Anantha· 1 shared A. Cooper· 1 shared A. Dorrie· 1 shared A. Kotlyarov· 1 shared A. Prasse· 1 shared A. Schwarzer· 1 shared A. Szyposzynska· 1 shared B. Jaeger· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Anantha

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1

A. Schwarzer, M. Oliveira, M.-J. Kleppa, S. D. Slattery, A. Anantha, A. Cooper, M. Hannink, A. Schambach, A. Dorrie, A. Kotlyarov, M. Gaestel, T. Hembrough, J. Levine, M. Luther, M. Stocum, , M. J. Kostura

This study identifies OMA1 activators that induce apoptosis in DLBCL cells via the ATF4-ISR pathway, showing efficacy in preclinical models.

bioRxiv · Jun 12, 2022Cancer Biology

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

L. Han, X. Wei, C. Liu, G. Volpe, Z. Zhuang, X. Zou, Z. Wang, T. Pan, Y. Yuan, X. Zhang, P. Fan, P. Guo, Y. Lai, Y. Lei, X. Liu, , Z. Liu

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Nature · Apr 13, 2022Peer-reviewedCell Biology

Screening of Chimeric GAA Variants in a Preclinical Study of Pompe Disease Results in Candidate Vector for Hematopoietic Stem Cell Gene Therapy

Y. Dogan, C. N. Barese, J. W. Schindler, J. K. Yoon, Z. Unnisa, S. Guda, M. E. Jacobs, C. Oborski, D. L. Clarke, A. Schambach, R. Pfeifer, C. Harper, C. Mason, N. P. van Til

This study screens chimeric GAA variants in a preclinical Pompe disease model, identifying a candidate vector for hematopoietic stem cell gene therapy that reduces glycogen accumulation and CNS vacuolation.

bioRxiv · Dec 28, 2021Bioengineering

Efficient in vivo genome editing mediated by stem cells-derived extracellular vesicles carrying designer nucleases

S. Bobis-Wozowicz, K. Kania, K. Nit, N. Blazowska, K. Kmiotek-Wasylewska, M. Paw, E. Karnas, A. Szyposzynska, M. Tyszka-Czochara, O. Woznicka, D. Boruczkowski, C. Mussolino, P. P. Łabaj, A. Schambach, Z. Madeja, , E. Zuba-Surma

This study demonstrates that stem cell-derived extracellular vesicles can deliver designer nucleases in vivo, achieving up to 50% gene knockout in the liver.

bioRxiv · Feb 25, 2021 · PreprintBioengineering

Airway Basal Cells show a dedifferentiated KRT17high Phenotype and promote Fibrosis in Idiopathic Pulmonary Fibrosis

B. Jaeger, J. C. Schupp, L. Plappert, O. Terwolbeck, G. Kayser, P. Engelhard, T. S. Adams, R. Zweigerdt, H. Kempf, S. Lienenklaus, W. Garrels, I. Nazarenko, D. Jonigk, M. Wygrecka, D. Klatt, , A. Prasse

This study identifies IPF-ABC as dedifferentiated KRT17high cells that promote fibrosis and shows SRC inhibition can reverse their profibrotic effects.

bioRxiv · Sep 4, 2020Cell Biology