Structural insights into regulation of TRPM7 divalent cation uptake by the small GTPase ARL15
L. Mahbub, G. Kozlov, P. Zong, S. Tetteh, T. Nethramangalath, C. Knorn, J. Jiang, A. Shahsavan, E. Lee, L. Yue, L. Runnels, K. Gehring
This study identifies ARL15 as a GTPase that binds CNNM2 and inhibits TRPM7-mediated divalent cation uptake, revealing molecular interactions and competitive regulation with PRL2.
bioRxiv · Jan 19, 2023Biochemistry