E. Lee

Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines

This study evaluates monoclonal antibody responses to XBB.1.5 vaccines by analyzing plasmablasts from vaccinated individuals and characterizing their binding and neutralization properties against SARS-CoV-2 variants.

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

This study shows that treatment timing affects the path to androgen receptor signaling inhibitor resistance in prostate cancer, with resistance arising through different mechanisms depending on the tumor context.

DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders

This study identifies a covalent handle that enables the degradation of multiple protein targets when appended to protein-targeting ligands.

Discovery and engineering of the antibody response against a prominent skin commensal

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

In vivo Imaging using Surface Enhanced Spatially Offset Raman Spectroscopy (SESORS): Balancing Sampling Frequency to Improve Overall Image Acquisition

This paper introduces SESORRS, a technique combining SERRS and SORS for in vivo tumor imaging, showing improved SNR and faster acquisition of deep-seated tumor data.

Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy

This study links structural and functional vascular dysfunction in brain metastases to pembrolizumab resistance by analyzing perfusion MRI data from 44 patients.

Functional Protein Dynamics in a Crystal

This paper develops methods to simulate protein dynamics in crystals and shows they accurately capture ligand-induced conformational changes.

IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs

This study shows IRF8 regulates enhancer landscapes and transcriptional programs in postnatal microglia, affecting their identity and response to disease.

Upregulation of the NKG2D ligand ULBP2 by JC polyomavirus infection promotes immune recognition by natural killer cells.

This study shows that NK cells can eliminate JCPyV-infected cells through NKG2D-ULBP2 interaction, suggesting this pathway as a potential immunotherapeutic target for PML.

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

This study identifies BET inhibition as a potential therapy for BRCA2-deficient pancreatic cancer by showing it enhances autophagy-dependent cell death in these cells.

Engrailed-1 Promotes Pancreatic Cancer Metastasis

This study shows EN1 promotes pancreatic cancer metastasis by repressing target genes and enhancing mesenchymal properties.

Structural insights into regulation of TRPM7 divalent cation uptake by the small GTPase ARL15

This study identifies ARL15 as a GTPase that binds CNNM2 and inhibits TRPM7-mediated divalent cation uptake, revealing molecular interactions and competitive regulation with PRL2.

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

This study develops TAG72-CAR T cells with antigen-dependent IL-12 signaling to enhance anti-tumor activity and systemic disease targeting in ovarian cancer.

CD244 regulates both innate and adaptive immune axes in melanoma by inhibiting autophagy-mediated M1 macrophage maturation

This study shows CD244 inhibits macrophage maturation in melanoma, enhancing T cell responses and improving tumor rejection when combined with PD-L1 blockade.

Zinc Fingers and Homeoboxes 2 is Required for Diethylnitrosamine-induced Liver Tumor Formation in C57BL/6 Mice

This study shows that Zhx2 acts as an oncogene in a liver tumor model, contradicting previous findings in human cell lines and other models, and correlates with higher ZHX2 expression in HCC patients.

Alveolar macrophage lipid burden correlates with clinical improvement in patients with Pulmonary Alveolar Proteinosis

This study shows that reduced lipid content in alveolar macrophages correlates with clinical improvement in patients with Pulmonary Alveolar Proteinosis.

Loss of FOXP3 function causes expansion of two pools of autoreactive T cells in patients with IPEX syndrome.

FOXP3 mutations in humans lead to expansion of autoreactive T cells from both effector and regulatory T cells that gain effector function.

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips

This paper establishes a method to create physiologically relevant oxygen gradients in a microfluidic intestine-on-a-chip model, supporting stable oxygen levels and intestinal barrier integrity.

Feedback in the β-catenin destruction complex imparts bistability and cellular memory

The paper shows that positive feedback in the β-catenin destruction complex creates bistability and memory in Wnt signaling, leading to switch-like cellular responses.

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

Towards a unified model of naive T cell dynamics across the lifespan

This study develops a unified model of naive CD4 and CD8 T cell dynamics across the mouse lifespan, revealing that survival capacity increases with age and that naive CD8 T cells are rapidly lost early in life.

MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1

This study identifies a novel pathway where MAP4K3 inhibits Sirtuin-1 to suppress LKB1-AMPK, thereby activating mTORC1 in response to amino acids.

Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR

This study identifies lomitapide, a cholesterol-lowering drug, as an mTORC1 inhibitor that induces autophagic cell death in cancer cells and enhances immune checkpoint blockade in preclinical models.

SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys

This study shows that SARS-CoV-2 vaccines induce neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, and batCoVs in monkeys.

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal region

This study identifies the N-terminal region of CHD7 as critical for its ATPase activity and nucleosome remodeling through interactions with the nucleosome acidic patch.

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.