L. Yue

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

This study shows that PPARγ enhances exosome biogenesis in fibroblast-like synoviocytes via the ESCRT pathway, and these exosomes containing ANXA1 alleviate osteoarthritis by inhibiting ERK phosphorylation and chondrocyte apoptosis.

This study uses single-cell transcriptomics to analyze human intracranial aneurysm tissue, identifying immune cell features linked to aneurysm rupture.

This study identifies ARL15 as a GTPase that binds CNNM2 and inhibits TRPM7-mediated divalent cation uptake, revealing molecular interactions and competitive regulation with PRL2.

The paper identifies FLVCR1 as essential for choline transport in mammals through integrative genetic analysis and functional studies.

This study identifies PLCβ2 as a key regulator of VEGF-induced vascular permeability by modulating calcium flux and PIP2 levels, showing therapeutic potential for diseases involving vascular leakage.

This replication study confirms some findings of the original study on RAF inhibitors and their effects on MAPK pathway activation but reports discrepancies in key experiments.

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

This study shows TRPM2 deficiency protects against atherosclerosis by inhibiting the TRPM2-CD36 inflammatory axis in macrophages, reducing plaque burden and inflammation.

This paper identifies aCPSF1 and terminator U-tract synergy in archaeal transcription termination, showing their roles in determining termination efficiency through KH domain binding and nuclease activity.

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

The paper uses computational models to identify immunogenic regions in the HIV proteome by analyzing HLA diversity and CD8 T-cell immune repertoires, offering a pipeline for vaccine design.

This paper identifies aCPSF1 as the first general transcription termination factor in Archaea, revealing its cleavage-dependent termination mechanism and evolutionary relationship to eukaryotic processes.