Cancer BiologybioRxiv
High-Throughput Functional Evaluation of BRCA2 Variants of Unknown Significance
M. Ikegami, S. Kohsaka, T. Ueno…·H. Mano
The paper develops a high-throughput method to evaluate BRCA2 variants of unknown significance, classifying 186 variants into neutral, intermediate, or deleterious categories with high sensitivity and specificity.
DOI 10.1038/s41467-020-16141-8