Author

A. Sienkiewicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

P. J. Lehner· 2 shared A. Naamati· 1 shared D. J. van den Boomen· 1 shared D. M. van Elsland· 1 shared E. J. Greenwood· 1 shared I. Berlin· 1 shared J. C. Williamson· 1 shared J. J. Neefjes· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

P. J. Lehner

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2 papers

Recent·Most cited

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

D. J. van den Boomen, A. Sienkiewicz, I. Berlin, M. L. Jongsma, D. M. van Elsland, J. P. Luzio, J. J. Neefjes, P. J. Lehner

The paper identifies C18orf8 as a core component of the Mon1-Ccz1 GEF for Rab7, showing its role in Rab7 activation, endosomal LDL trafficking, and NPC1-dependent lysosomal cholesterol export.

bioRxiv · Nov 8, 2019Cell Biology

Promiscuous targeting of cellular proteins by Vpr drives massive proteomic remodelling in HIV-1 infection

E. J. Greenwood, J. C. Williamson, A. Sienkiewicz, A. Naamati, N. J. Matheson, P. J. Lehner

The paper identifies Vpr as the main driver of proteomic changes in HIV-1 infection by degrading multiple host proteins.

bioRxiv · Jan 8, 2019Microbiology