The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm
M. Hamdorf, T. Imhof, B. A. Bailey-Elkin, J. Betz, S. J. Theobald, A. Simonis, V. Di Cristanziano, L. Gieselmann, F. Dewald, C. Lehmann, M. Augustin, F. Klein, M. A. Alcazar, R. Rogisch, M. Fabri, , F. Bock
This study shows that SARS-CoV-2's ORF8 protein binds to human dendritic cells, induces cytokine storms, and may be a target for therapeutic intervention.
bioRxiv · Jun 6, 2022 · PreprintImmunology