Author

L. Gieselmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7

Signature Assays, Organisms & Methods

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Organism:human· 7 Assay:proteomics· 6 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

F. Klein· 7 shared M. S. Ercanoglu· 5 shared P. Schommers· 5 shared C. Kreer· 4 shared H. Gruell· 4 shared K. Vanshylla· 3 shared M. Koch· 3 shared M. Schlotz· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersImmunology

F. Klein

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7 papers

Recent·Most cited

Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning

C. E. Radford, P. Schommers, L. Gieselmann, K. H. Crawford, B. Dadonaite, T. C. Yu, A. S. Dingens, J. Overbaugh, F. Klein, J. D. Bloom

This study maps the neutralizing specificity of human anti-HIV serum using deep mutational scanning to identify Env mutations affecting neutralization by polyclonal sera.

bioRxiv · Mar 23, 2023Immunology

Probabilities of HIV-1 bNAb development in healthy and chronically infected individuals

C. Kreer, C. Lupo, M. S. Ercanoglu, L. Gieselmann, N. Spisak, J. Grossbach, M. Schlotz, P. Schommers, H. Gruell, L. Dold, A. Beyer, A. Nourmohammad, T. Mora, A. Walczak, F. Klein

The paper uses sequence analysis to predict the likelihood of HIV-1 broadly neutralizing antibody (bNAb) development in healthy and infected individuals, finding that chronic infection is not required for bNAb generation.

bioRxiv · Jul 11, 2022Immunology

The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm

M. Hamdorf, T. Imhof, B. A. Bailey-Elkin, J. Betz, S. J. Theobald, A. Simonis, V. Di Cristanziano, L. Gieselmann, F. Dewald, C. Lehmann, M. Augustin, F. Klein, M. A. Alcazar, R. Rogisch, M. Fabri, , F. Bock

This study shows that SARS-CoV-2's ORF8 protein binds to human dendritic cells, induces cytokine storms, and may be a target for therapeutic intervention.

bioRxiv · Jun 6, 2022 · PreprintImmunology

No substantial pre-existing B cell immunity against SARS-CoV-2 in healthy adults

M. S. Ercanoglu, L. Gieselmann, S. Daehling, N. Poopalasingam, S. Detmer, M. Koch, M. Korenkov, S. Halwe, M. Kluever, V. Di Cristanziano, U. H. Janicki, M. Schlotz, J. Worczinski, B. Gathof, H. Gruell, , F. Klein

The paper analyzes B cell immunity in unexposed adults and finds no substantial pre-existing antibody or B cell response to SARS-CoV-2.

bioRxiv · Sep 8, 2021Immunology

Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2

K. Vanshylla, V. Di Cristianziano, F. Kleipass, F. Dewald, P. Schommers, L. Gieselmann, H. Gruell, M. Schlotz, M. S. Ercanoglu, R. Stumpf, P. Mayer, E. Heger, W. Johannis, C. Horn, I. Suarez, , F. Klein

This study examines the kinetics and correlates of the SARS-CoV-2 neutralizing antibody response in 963 recovered individuals over 10 months, finding variations in antibody persistence and identifying factors predicting neutralizing activity.

bioRxiv · Jan 26, 2021 · PreprintImmunology

Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients

C. Kreer, M. Zehner, T. Weber, C. Rohde, S. Halwe, M. S. Ercanoglu, L. Gieselmann, M. Korenkov, H. Gruell, P. Schommers, K. Vanshylla, V. Di Cristanziano, H. Janicki, R. Brinker, A. Ashurov, , F. Klein

This study isolates potent SARS-CoV-2-neutralizing antibodies from COVID-19 patients as early as 8 days post-diagnosis and identifies precursor B cells in healthy individuals.

bioRxiv · Jun 12, 2020Immunology

openPrimeR for multiplex amplification of highly diverse templates

C. Kreer, M. Doering, N. Lehnen, M. S. Ercanoglu, L. Gieselmann, D. Luca, K. Jain, P. Schommers, N. Pfeifer, F. Klein

The paper introduces openPrimeR, an R-based tool for designing multiplex PCR primers for highly diverse templates, and demonstrates its effectiveness in amplifying immunoglobulins.

bioRxiv · Nov 20, 2019Immunology