Author

A. Spinello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 3 Organism:human· 2 Assay:structural biology· 2 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. MONARI· 2 shared A. Terenzi· 2 shared E. Bignon· 2 shared G. Barone· 2 shared L. D'Anna· 2 shared S. Grandemange· 2 shared T. Miclot· 2 shared A. Magistrato· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

A. MONARI

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Author profile →

3 papers

Recent·Most cited

Mechanism of the Covalent Inhibition of Human Transmembrane Protease Serine 2 as an Original Antiviral Strategy

A. Spinello, L. D'Anna, E. Bignon, T. Miclot, S. Grandemange, A. Terenzi, G. Barone, F. Barbault, A. MONARI

This study uses multiscale molecular modeling to investigate the mechanism of TMPRSS2 inhibition by Nafamostat, revealing its free-energy profile and structural dynamics.

bioRxiv · Apr 23, 2023Biophysics

Predicting the Three-dimensional Structure of the c-KIT Oncogene Promoter and the Dynamics of Strongly Coupled Guanine-Quadruplexes

E. Bignon, A. Spinello, T. Miclot, L. D'Anna, C. Ducani, S. Grandemange, G. Barone, A. MONARI, A. Terenzi

The paper predicts the 3D structure of the c-KIT promoter's G4s and shows how their coupling affects structure formation and drug discovery potential.

bioRxiv · Feb 23, 2023 · PreprintBiophysics

Allosteric Cross-Talk Among SARS-CoV-2 Spike's Receptor-Binding Domain Mutations Triggers an Effective Hijacking of Human Cell Receptor

A. Spinello, A. Saltalamacchia, J. Borisek, A. Magistrato

This paper uses molecular dynamics simulations to analyze how mutations in SARS-CoV-2 Spike's RBD affect ACE2 binding and antibody evasion, revealing mechanisms behind increased viral transmissibility.

bioRxiv · Apr 30, 2021Biophysics