Doxorubicin induces caspase-mediated proteolysis of KV7.1
A. Strigli, M. Schwake, C. Raab, S. Hessler, T. Huth, A. J. T. Schuldt, C. Alzheimer, T. Friedrich, P. W. Burrdige, M. Luedde
This study identifies caspase-mediated proteolysis of Kv7.1 as a novel mechanism regulated by doxorubicin, leading to reduced cardiac potassium currents.
bioRxiv · Feb 3, 2018Biochemistry