T. Huth

Two-Dimensional-Dwell-Time Analysis of Ion Channel Gating using High Performance Computing Clusters

This paper introduces an HPC-based method to improve 2D-Dwell-Time analysis of ion channel gating, enabling reliable extraction of Markov models from noisy data.

Doxorubicin induces caspase-mediated proteolysis of KV7.1

This study identifies caspase-mediated proteolysis of Kv7.1 as a novel mechanism regulated by doxorubicin, leading to reduced cardiac potassium currents.