Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure
C. M. Pavelec, A. Young, H. L. Luviano, E. E. Orrell, A. Szagdaj, N. Poudel, A. G. Wolpe, S. H. Thomas, S. Yeudall, C. Upchurch, M. D. Okusa, B. E. Isakson, M. J. Wolf, N. Leitinger
This study shows that PANX1 deficiency in cardiomyocytes reduces glycolytic metabolism and protects against cardiac hypertrophy in non-ischemic heart failure by decreasing neutrophil recruitment.
bioRxiv · Dec 29, 2023 · PreprintPhysiology