A. Young

Secreted exosomes induce filopodia formation

This study identifies exosomes carrying THSD7A as regulators of filopodia formation in both cancer cells and neurons, mediated through Cdc42 activation.

Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure

This study shows that PANX1 deficiency in cardiomyocytes reduces glycolytic metabolism and protects against cardiac hypertrophy in non-ischemic heart failure by decreasing neutrophil recruitment.

Simple Design for Membrane-Free Microphysiological Systems to Model the Blood-Tissue Barriers

This paper introduces a membrane-free microphysiological system for modeling blood-tissue barriers, demonstrating a simple design that enables direct endothelial-epithelial contact and 3D transport.

Evolution of sex differences in cooperation: the role of trade-offs with dispersal

This study tests hypotheses about sex differences in cooperation by analyzing dispersal patterns in white-browed sparrow weavers, finding support for the Dispersal trade-off hypothesis over the Philopatry hypothesis.

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

Gemcitabine plus nab-paclitaxel preserves skeletal and cardiac mass and function in a murine model of pancreatic cancer cachexia

This study shows that gemcitabine plus nab-paclitaxel reduces tumor burden and prevents muscle and cardiac wasting in a murine model of pancreatic cancer cachexia.

Objective assessment of visual attention in toddlerhood

This study assesses visual attention in toddlers using eye-tracking data from 350 participants and introduces a shared data resource for research.

C-terminal conformational changes in SCF-D3/MAX2 ubiquitin ligase are required for KAI2-mediated signaling

This study investigates the role of MAX2 C-terminal helix conformational changes in KAR/KL and SL signaling, showing conservation of its function between pathways.

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus

This study shows that dysregulated CD71 in T cells increases iron uptake, disrupts mitochondrial function, and drives inflammation in SLE, with CD71 blockade improving outcomes.

Prolactin and the shared regulation of parental care and cooperative helping in white-browed sparrow weaver societies

This study examines how prolactin levels correlate with parental and helper provisioning behavior in white-browed sparrow weavers, suggesting a shared regulatory mechanism for parental care and cooperative helping.

Ablation of endogenously cycling adult cardiomyocytes worsens myocardial function after injury

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

This study identifies two enhancers regulating IL2RA expression in T cells, showing how their cell-type-specific effects influence autoimmune diabetes risk.

SNAPflex: a paper-and-plastic device for instrument-free RNA and DNA extraction from whole blood

SNAPflex is a low-cost, portable device for extracting RNA and DNA from whole blood without instruments, showing improved performance over traditional methods for HIV and Plasmodium.

Beach environmental DNA fills gaps in photographic biomonitoring to track spatiotemporal community turnover across 82 phyla

This paper compares eDNA metabarcoding and photographic observations to assess biodiversity and community turnover across 82 phyla, finding eDNA captures seasonal changes and links protected areas to better-sampled sites.