Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of Phosphodiesterase 2A
S. Delhaye, M. Jarjat, A. Boulksibat, C. Sanchez, A. Tempio, A. Turtoi, M. Giorgi, S. Lacas-Gervais, G. Baj, C. Rovere, V. Trezza, M. Pellegrini, T. Maurin, E. Lalli, B. Bardoni
This study investigates the role of PDE2A in socio-cognitive deficits by analyzing Pde2a+/- mice, revealing microglia activation and AMPAR trafficking defects linked to cognitive impairments.
bioRxiv · Nov 6, 2023Animal Behavior & Cognition