M. Pellegrini

This study investigates the role of PDE2A in socio-cognitive deficits by analyzing Pde2a+/- mice, revealing microglia activation and AMPAR trafficking defects linked to cognitive impairments.

This study shows that IL-1B-mediated inflammation drives ineffective erythropoiesis in early-stage MDS and that canakinumab can reduce transfusion dependence in patients with DNMT3A and TET2 mutations.

The paper examines a case where molecular phylogenetic analysis misclassified a plant species due to a sampling error, emphasizing the importance of morphology in phylogenetic studies.

The paper identifies transcriptional changes in endothelial cells due to environmental factors like shear stress and heterotypic interactions, showing their impact on gene expression independent of genetic background.

This study identifies UTX as a key X-linked epigenetic regulator causing sex differences in NK cell function, with males showing reduced IFN-γ production despite higher numbers.

This study shows that canonical Wnt signaling induces endocytosis of focal adhesion proteins and integrin beta-1, affecting cell adhesion and signaling.

The paper compares non-lesional and lesional lupus skin to show they share inflammatory features that activate CD16+ dendritic cells.

This study shows that PFKFB3 depletion in β-cells under diabetogenic stress increases β-cell replication by removing damaged cells, improving β-cell function and mass.

This study examines how hibernation affects epigenetic aging in yellow-bellied marmots using epigenetic clocks and pacemakers, finding that aging slows during hibernation.

This study shows that live E. coli induces stronger immune responses, including higher IL6 and prostaglandin levels, leading to preterm labor in Rhesus macaques compared to LPS.

The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.

The paper compares embryo proper and suspensor transcriptomes across plants with different suspensor morphologies, identifying shared and specific transcription factors involved in early embryo differentiation.

This study shows that in vitro cellular aging models can reflect multi-tissue epigenetic aging in vivo, using DNAmCULTURE as a measure that tracks aging across tissues and responds to interventions.

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

This study investigates how prior pair-bonding experience in prairie voles affects future bonding behavior, finding that separation duration from the first partner influences the ability to form a new bond.

This study shows that a disulfide bond in ToxR's periplasmic domain increases its affinity for ToxS and bile-salts, stabilizing its structure and function.

The paper examines how soil salinity affects cowpea nodule microbiomes and identifies halotolerant PGPR strains that enhance plant growth under salinity stress.

This study compares two methods for expanding human corneal endothelial cells in vitro, finding that low mitogenic conditions better preserve cell identity and that senescence occurs with continuous passaging.

The paper analyzes correlations between inflammatory molecular signatures and cancer types, finding significant associations with tumor stage, gender, and patient vital status in specific cancers.

This study determines the structure of PSHCP, a highly conserved protein in cyanobacteria, revealing it contains a Tudor domain with RNA-binding activity, suggesting a role in translation.

This study identifies a missense mutation in MLKL causing lethal neonatal inflammation in mice and links it to increased frequency in human autoinflammatory disease.

This study investigates how TLQP-21 levels change in mice after glucose load, showing increased plasma levels at 120 minutes and decreased pancreatic staining at 30 minutes.

This study compares corneal biomechanics between patients with ocular graft-versus-host disease and healthy controls, finding reduced corneal hysteresis and resistance factor in oGVHD patients, with correlations between biomechanical parameters and disease severity and MMP-9 levels.

The paper identifies DNA Methylation Valleys (DMVs) in soybean and Arabidopsis seed genomes, showing they are enriched in transcription factor genes and remain hypomethylated throughout development.

The paper uses dual RNAseq to analyze leprosy lesions, linking bacterial states to host immune responses through type I IFNs and antibody pathways.

This study identifies two mechanisms for pseudogenization in prokaryotes using phylogenomic analysis of Mycobacterium leprae and other bacteria.

The paper investigates the role of the peach RGF/GLV peptide pCTG134 in an auxin-ethylene regulatory circuit, showing its involvement in root hair formation and hormonal crosstalk.

The paper presents a training model to teach UNIX command-line tools to biomedical researchers with little to no prior knowledge.