Author

A. Thokkadam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. J. Link· 2 shared T. Do· 2 shared A. De Chellis· 1 shared A. Wang· 1 shared B. Nemmaru· 1 shared J. Douglass· 1 shared J. M. Yarbrough· 1 shared M. Brynildsen· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. J. Link

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin

A. Thokkadam, T. Do, X. Ran, M. Brynildsen, Z. J. Yang, A. J. Link

This study uses a high-throughput screen to analyze ubonodin variants, identifying structure-activity relationships and a variant with improved antimicrobial activity against Burkholderia cenocepacia.

ACS Central Science · Mar 1, 2023Peer-reviewedBiochemistry

The Anti-Burkholderia Lasso Peptide Ubonodin Co-Opts the Siderophore Receptor PupB for Cellular Entry

T. Do, A. Thokkadam, R. Leach, A. J. Link

This study identifies PupB as an outer membrane receptor required for ubonodin uptake in Burkholderia cepacia, revealing that transport, not target inhibition, determines its activity.

bioRxiv · Mar 9, 2022 · PreprintMicrobiology

Supercharged Cellulases Show Reduced Non-Productive Binding, But Enhanced Activity, on Pretreated Lignocellulosic Biomass

B. Nemmaru, J. Douglass, J. M. Yarbrough, A. De Chellis, S. Shankar, A. Thokkadam, A. Wang, S. P. S. Chundawat

This study shows that supercharging cellulase surface charge improves hydrolytic activity on pretreated biomass by reducing non-productive binding.

bioRxiv · Oct 17, 2021 · PreprintBioengineering