T. Do

Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

This study evaluates cipargamin's efficacy against Babesia species and identifies resistance mechanisms, showing its effectiveness as an anti-babesial drug but limitations due to resistance, with combination therapy with tafenoquine offering potential.

CREID- A ChemoReceptor-Effector Interaction Database

CREID provides a database of bacterial chemoreceptor-effector interactions, offering insights into bacterial sensing mechanisms and applications for biosensor development.

Genome Mining and Discovery of Imiditides, a Novel Family of RiPPs with a Class-defining Aspartimide Modification

This paper discovers a novel family of RiPPs called imiditides through genome mining, revealing 670 BGCs and demonstrating heterologous production of mNmaAM with a unique aspartimide modification.

A High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin

This study uses a high-throughput screen to analyze ubonodin variants, identifying structure-activity relationships and a variant with improved antimicrobial activity against Burkholderia cenocepacia.

M. tuberculosis microvariation is common and is associated with transmission: analysis of three years prospective universal sequencing in England

This study identifies microvariation in M. tuberculosis strains using sequencing data from England, finding that mixed infections are associated with increased tuberculosis transmission.

The Anti-Burkholderia Lasso Peptide Ubonodin Co-Opts the Siderophore Receptor PupB for Cellular Entry

This study identifies PupB as an outer membrane receptor required for ubonodin uptake in Burkholderia cepacia, revealing that transport, not target inhibition, determines its activity.

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

The paper shows that ActH stabilizes metals in the LytH active site to activate amidase activity, revealing a general strategy for amidase activation.

The C. albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells.

This study reveals that Candidalysin polymerizes in solution to form membrane pores, damaging epithelial cells, and identifies polymerization as a therapeutic target for candidiasis.

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.

The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity

This study shows that controlling the length of lipoteichoic acid (LTA) polymers in Staphylococcus aureus is critical for cell size, envelope integrity, and antibiotic resistance.

Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology

The paper introduces an improved scRNA-Seq protocol, Seq-Well S^3, which enhances transcript capture and gene detection efficiency, and applies it to study inflammatory skin diseases.

The cell cycle in Staphylococcus aureus is regulated by an amidase that controls peptidoglycan synthesis

This study identifies an amidase complex that spatially regulates peptidoglycan synthesis in S. aureus, controlling cell growth and division by modulating synthase activity and movement.