Author

X. Ran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Z. J. Yang· 2 shared A. C. H. Liu· 1 shared A. Garzia· 1 shared A. J. Link· 1 shared A. Lemoff· 1 shared A. Luo· 1 shared A. Thokkadam· 1 shared C. Zhang· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

Z. J. Yang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Metabolomics unveiled the impact of alterations in nucleotide glucose metabolism on palmitic acid-induced TLR4 activation in THP-1 macrophages

N. Wu, X. Ran, J. Wang, P. Wang, L. Li, Y. She, Y. Luo, X. Li, Y. Jia, Y. Huang

This study uses metabolomics to show that palmitic acid alters N-glycosylation-related metabolites in THP-1 macrophages, linking them to TLR4 activation and inflammation.

bioRxiv · Jan 2, 2024 · PreprintImmunology

Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection

L. Spiga, R. T. Fansler, Y. R. Perera, N. G. Shealy, M. J. Munneke, T. P. Torres, H. David, A. Lemoff, X. Ran, K. L. Richardson, N. Pudlo, E. C. Martens, Z. J. Yang, E. P. Skaar, M. X. Byndloss, , W. Zhu

This study shows that the commensal bacterium Bacteroides thetaiotaomicron acquires iron using siderophores from Salmonella, evading host sequestration by lipocalin-2 and allowing Salmonella to bypass nutritional immunity.

bioRxiv · Jun 25, 2023 · PreprintMicrobiology

Ulinastatin Ameliorates Cardiac Ischemia/Reperfusion Injury via Inhibiting the tissue kallikrein-kinin system

X. Ran, H. Ruan, S.-s. Li, R. Wu, A. Luo, Q. Zhang

This study shows ulinastatin reduces cardiac ischemia/reperfusion injury by inhibiting the tissue kallikrein-kinin system and its downstream signaling pathways.

bioRxiv · Feb 21, 2023 · PreprintCell Biology

A High-Throughput Screen Reveals the Structure-Activity Relationship of the Antimicrobial Lasso Peptide Ubonodin

A. Thokkadam, T. Do, X. Ran, M. Brynildsen, Z. J. Yang, A. J. Link

This study uses a high-throughput screen to analyze ubonodin variants, identifying structure-activity relationships and a variant with improved antimicrobial activity against Burkholderia cenocepacia.

bioRxiv · Dec 13, 2022Biochemistry

Rapid modeling of experimental molecular kinetics with simple electronic circuits instead of with complex differential equations

Y. Deng, D. R. Beahm, X. Ran, T. G. Riley, R. Sarpeshkar

The paper maps biochemical reaction kinetics to electronic circuits, enabling intuitive and accurate modeling without complex differential equations.

bioRxiv · May 11, 2022Bioengineering

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

J.-H. Choi, X. Zhang, C. Zhang, D. L. Dai, J. Luo, R. Ladak, Q. Li, S. Wiebe, A. C. H. Liu, X. Ran, J. Yang, P. Naeli, A. Garzia, L. Zhou, N. Mahmood, , N. Sonenberg

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology