Author

A. Thoma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. P. Lightfoot· 3 shared N. Al-Shanti· 2 shared R. G. Cooper· 2 shared G. Nye· 1 shared H. Degens· 1 shared H. L. Bond· 1 shared K. E. Earl· 1 shared K. Goljanek-Whysall· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

A. P. Lightfoot

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Author profile →

3 papers

Recent·Most cited

A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.

A. Thoma, H. L. Bond, T. Akter-Miah, N. Al-Shanti, H. Degens, V. Pekovic-Vaughan, A. P. Lightfoot

This study shows that MHC-I overexpression and type I IFNs together worsen mitochondrial dysfunction in human skeletal myoblasts.

bioRxiv · Apr 10, 2024Cell Biology

Major Histocompatibility Complex (MHC) I-induced Endoplasmic Reticulum (ER) Stress mediates the secretion of pro-inflammatory muscle-derived cytokines

A. Thoma, K. E. Earl, R. G. Cooper, K. Goljanek-Whysall, A. P. Lightfoot

This study shows that MHC I overexpression in muscle cells induces ER stress, leading to pro-inflammatory cytokine release, which is reduced by salubrinal.

bioRxiv · Jun 29, 2022Cell Biology

Eukarion-134 attenuates endoplasmic reticulum stress-induced mitochondrial dysfunction in human skeletal muscle cells

A. Thoma, M. Lyon, N. Al-Shanti, G. Nye, R. G. Cooper, A. P. Lightfoot

This study shows that EUK-134 reduces ER stress-induced mitochondrial dysfunction in skeletal muscle cells by mitigating ROS generation and improving mitochondrial function.

bioRxiv · Jun 10, 2020Physiology