Exponentially decreasing exposure of antigen generates anti-inflammatory T-cell responses
A. Esrafili, J. Kupfer, A. Thumsi, M. JAGGARAPU, A. Suresh, A. Talitckii, T. Khodaei, S. Swaminathan, S. Mantri, M. Peet, A. Acharya
This study shows that reducing antigen exposure exponentially decreases pro-inflammatory T cell responses and promotes regulatory T cells in a mouse model of rheumatoid arthritis.
bioRxiv · Sep 15, 2023 · PreprintImmunology