A. Suresh

Acute kidney injury triggers hypoxemia by inducing intravascular neutrophil retention that reduces lung capillary blood flow

This study identifies that acute kidney injury causes hypoxemia through intravascular neutrophil retention in lung capillaries, reducing blood flow without lung edema.

Theileria annulata Infection Promotes p53 suppression, Genomic Instability and DNA deaminase APOBEC3H upregulation leading to cancer-like phenotype in host cells

This study identifies somatic mutations and genomic instability in Theileria annulata-infected leukocytes, linking them to cancer-like phenotypes through ROS1, TP53 suppression, and APOBEC3H upregulation.

Exponentially decreasing exposure of antigen generates anti-inflammatory T-cell responses

This study shows that reducing antigen exposure exponentially decreases pro-inflammatory T cell responses and promotes regulatory T cells in a mouse model of rheumatoid arthritis.

Conformationally responsive dyes enable protein-adaptive Differential Scanning Fluorometry

This paper introduces paDSF, a protein-adaptive Differential Scanning Fluorometry method that improves compatibility with proteins and expands observable processes.

Establishment and Characterization of Three Novel CAF Cell Lines from HNSCC Patients

This study establishes three novel CAF cell lines from HPV-negative HNSCC patients to study tumor-stroma interactions and identify new therapeutic targets.

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages

This paper shows that MYC overexpression in cancers suppresses immune surveillance by inhibiting pro-inflammatory macrophages, and this immune evasion can be reversed by combined PDL1 and CTLA4 blockade.

Establishment and characterization of novel autologous pair primary cultures from two Indian non-habitual tongue carcinoma patients

The paper establishes and characterizes novel autologous primary cultures from two Indian non-habitual tongue carcinoma patients to study tumor-stroma interactions.

Effect of Variations in the Conserved Residues E371 and S359 on the Structural Dynamics of Protein Z Dependent Protease Inhibitor (ZPI): A Molecular Dynamic Simulation Study

This study uses molecular dynamics simulations to analyze how mutations at conserved residues E371 and S359 affect the structural dynamics of ZPI, revealing their role in RCL flexibility and protease inhibition.

Bt cotton sustainability needs integration of complementary technologies for the cotton farmers in India.

The paper argues for integrating complementary technologies to sustain Bt cotton adoption in India due to concerns about biased conclusions on its long-term impact.

Three Essential Resources to Improve Differential Scanning Fluorimetry (DSF) Experiments

The paper provides three resources to improve DSF experiments: an interactive theoretical framework, practical tips, and online data analysis tools, available at DSFworld.

Enabling Precision Medicine via standard communication of NGS provenance, analysis, and results

The paper introduces the BioCompute framework to standardize genomic data reporting, enabling reproducibility and interoperability in precision medicine.

High-risk human papillomavirus in oral cavity squamous cell carcinoma

This study examines HPV's role in OSCC by analyzing multiple assays and molecular markers, finding that HPV DNA alone is not reliable for detecting active infection and that HPV markers do not correlate with patient survival.

A minimal set of internal control genes for gene expression studies in head and neck squamous cell carcinoma

The paper identifies RPL30 and RPL27 as stable internal control genes for gene expression studies in head and neck squamous cell carcinoma using microarray, RNA-seq, and qPCR data.