CAR T cells recognizing CD276 and Dual-CAR T cells against CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
A. Timpanaro, C. Piccand, D. Dzhumashev, S. Anton-Joseph, J. Moser, A. Robbi, J. Roessler, M. Bernasconi
This study evaluates CD276 and FGFR4-targeting CAR T cells for rhabdomyosarcoma treatment, showing in vitro efficacy and in vivo tumor clearance, but limited effectiveness in low antigen expression tumors.
bioRxiv · Sep 5, 2023Cancer Biology