Cancer BiologybioRxiv
CAR T cells recognizing CD276 and Dual-CAR T cells against CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
A. Timpanaro, C. Piccand, D. Dzhumashev…·M. Bernasconi
This study evaluates CD276 and FGFR4-targeting CAR T cells for rhabdomyosarcoma treatment, showing in vitro efficacy and in vivo tumor clearance, but limited effectiveness in low antigen expression tumors.
DOI 10.1186/s13046-023-02838-3