Author

A. Vanderstichele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

E. Maritschnegg· 2 shared A. Siekierska· 1 shared A. van den Broeck· 1 shared C. C. Valentine· 1 shared D. Lambrechts· 1 shared D. Nachmanson· 1 shared E. Hermans· 1 shared E. Loter· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

E. Maritschnegg

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2 papers

Recent·Most cited

The tumor suppressor protein PTEN undergoes amyloid-like aggregation in tumor cells.

F. Claes, E. Maritschnegg, G. De Baets, A. Siekierska, M. Saiz Rubio, M. Ramakers, E. Michiels, F. De Smet, J. Depreeuw, I. Vergote, A. Vanderstichele, A. van den Broeck, S. Olbrecht, E. Hermans, F. Amant, , J. Schymkowitz

This study shows PTEN, a tumor suppressor, undergoes amyloid-like aggregation in tumor cells, both due to mutations and dysregulated protein homeostasis, and links this aggregation to poor clinical outcomes.

bioRxiv · Nov 30, 2020 · PreprintCancer Biology

Ultra-sensitive sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan

J. J. Salk, K. Loubet-Senear, E. Maritschnegg, C. C. Valentine, L. N. Williams, R. Horvat, A. Vanderstichele, D. Nachmanson, K. T. Baker, M. J. Emond, E. Loter, T. Soussi, L. A. Loeb, R. Zeillinger, P. Speiser, R. A. Risques

This study uses ultra-sensitive sequencing to detect TP53 mutations in normal tissues across age, showing that age-related mutations share clonal selection traits with tumor mutations.

bioRxiv · Nov 4, 2018Cancer Biology