Cancer BiologybioRxivPreprint
The tumor suppressor protein PTEN undergoes amyloid-like aggregation in tumor cells.
F. Claes, E. Maritschnegg, G. De Baets…·J. Schymkowitz
This study shows PTEN, a tumor suppressor, undergoes amyloid-like aggregation in tumor cells, both due to mutations and dysregulated protein homeostasis, and links this aggregation to poor clinical outcomes.
DOI 10.1101/2020.11.30.402115