Cancer BiologybioRxiv
Ultra-sensitive sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan
J. J. Salk, K. Loubet-Senear, E. Maritschnegg…·R. A. Risques
This study uses ultra-sensitive sequencing to detect TP53 mutations in normal tissues across age, showing that age-related mutations share clonal selection traits with tumor mutations.
DOI 10.1016/j.celrep.2019.05.109