Author

F. Amant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Cleret-Buhot· 1 shared A. Emond· 1 shared A. Siekierska· 1 shared A. van den Broeck· 1 shared A. Vanderstichele· 1 shared B. C. Mindt· 1 shared B. K. van der Veer· 1 shared C. Duerr· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. Cleret-Buhot

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3 papers

Recent·Most cited

Wnt/β-catenin inhibition disrupts drug-tolerance in isogenic carboplatin-resistant models of Triple-Negative Breast Cancer.

W. A. Abreu de Oliveira, S. Moens, Y. El Laithy, B. K. van der Veer, P. Athanasouli, E. E. Cortesi, M. F. Baietti, K. P. Koh, J.-J. Ventura, F. Amant, D. Annibali, F. Lluis

This study shows that inhibiting Wnt/β-catenin signaling resensitizes carboplatin-resistant TNBC models to chemotherapy, suggesting a synergistic therapeutic strategy.

bioRxiv · May 21, 2021Cancer Biology

The tumor suppressor protein PTEN undergoes amyloid-like aggregation in tumor cells.

F. Claes, E. Maritschnegg, G. De Baets, A. Siekierska, M. Saiz Rubio, M. Ramakers, E. Michiels, F. De Smet, J. Depreeuw, I. Vergote, A. Vanderstichele, A. van den Broeck, S. Olbrecht, E. Hermans, F. Amant, , J. Schymkowitz

This study shows PTEN, a tumor suppressor, undergoes amyloid-like aggregation in tumor cells, both due to mutations and dysregulated protein homeostasis, and links this aggregation to poor clinical outcomes.

bioRxiv · Nov 30, 2020 · PreprintCancer Biology

The pleiotropic effects of the MNK1/2-eIF4E axis support immune suppression and metastasis in a model of postpartum breast cancer.

Q. Guo, M. Bartish, C. Goncalves, F. Huang, S. S. Krisna, S. Preston, A. Emond, V. Z. Li, C. Duerr, Y. Gui, A. Cleret-Buhot, P. Thebault, H. Lefrere, L. Lenaerts, D. Plourde, , W. H. Miller

This study shows that the MNK1/2-eIF4E axis promotes immune suppression and metastasis in postpartum breast cancer by affecting both tumor and non-tumor cells.

bioRxiv · Sep 7, 2020 · PreprintCancer Biology