Author

A. Varkey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

E. D. S. Hales· 2 shared P. L. Collins· 2 shared A. G. Freud· 1 shared A. Saadey· 1 shared A. Yan· 1 shared C. D. Eisele· 1 shared C. Farias Amorim· 1 shared C. I. de Oliveira· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

E. D. S. Hales

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2 papers

Recent·Most cited

Pathogenic CD8 T cell responses are driven by neutrophil-mediated hypoxia in cutaneous leishmaniasis.

E. A. Fowler, C. Farias Amorim, K. Mostacada, A. Yan, L. Amorim Sacramento, R. A. Stanco, E. D. S. Hales, A. Varkey, W. Zong, G. D. Wu, C. I. de Oliveira, P. L. Collins, F. O. Novais

The paper shows that hypoxia, driven by neutrophils, promotes cytolytic CD8 T cell function in cutaneous leishmaniasis lesions, correlating with disease severity.

bioRxiv · Oct 18, 2023 · PreprintImmunology

Aiolos modulates the TFH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25

K. A. Read, D. M. Jones, S. Pokhrel, E. D. S. Hales, A. Varkey, J. A. Tuazon, C. D. Eisele, O. Abdouni, A. Saadey, R. T. Warren, M. D. Powell, J. M. Boss, E. A. Hemann, J. S. Yount, H. E. Ghoneim, , K. J. Oestreich

This study identifies Aiolos as a regulator of TFH and CD4-CTL differentiation, showing it modulates the Zfp831/TCF-1/Bcl-6 axis and suppresses the cytotoxic gene program.

bioRxiv · May 18, 2022 · PreprintImmunology