Author

E. A. Hemann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:non-human primate· 1

Frequent Co-Authors

J. S. Yount· 3 shared A. C. Eddy· 2 shared A. Forero· 2 shared M. Gale· 2 shared A. C. Walls· 1 shared A. D. Kenney· 1 shared A. G. Freud· 1 shared A. Garcia-Sastre· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersImmunology

J. S. Yount

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Innate immune control of influenza virus interspecies adaptation

P. J. Denz, S. Speaks, A. D. Kenney, A. C. Eddy, J. L. Papa, J. Roettger, S. C. Scace, E. A. Hemann, A. Forero, R. J. Webby, A. S. Bowman, J. S. Yount

This study shows that IFITM3 deficiency in mice allows avian influenza viruses to infect and adapt more effectively, suggesting a role for IFITM3 in preventing zoonotic virus emergence.

bioRxiv · Aug 23, 2023 · PreprintMicrobiology

MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-resistant Staphylococcus aureus infection

M. De, K. B. Hisert, W. C. Liles, A. M. Manicone, E. A. Hemann, M. E. Long

This study shows MEK1/2 inhibitors reduce inflammation in CF macrophages and improve outcomes in MRSA-infected mice without affecting pathogen clearance.

bioRxiv · Jan 22, 2023 · PreprintImmunology

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunity

E. A. Hemann, M. L. Knoll, C. R. Wilkins, C. Subra, R. Green, A. Garcia-Sastre, P. Thomas, L. Trautmann, R. Ireton, Y.-M. Loo, M. Gale

This paper identifies a small molecule RIG-I agonist, KIN1148, that enhances influenza vaccine immunity by activating non-canonical RIG-I pathways to boost both antibody and T cell responses.

bioRxiv · Sep 20, 2022 · PreprintImmunology

Aiolos modulates the TFH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25

K. A. Read, D. M. Jones, S. Pokhrel, E. D. S. Hales, A. Varkey, J. A. Tuazon, C. D. Eisele, O. Abdouni, A. Saadey, R. T. Warren, M. D. Powell, J. M. Boss, E. A. Hemann, J. S. Yount, H. E. Ghoneim, , K. J. Oestreich

This study identifies Aiolos as a regulator of TFH and CD4-CTL differentiation, showing it modulates the Zfp831/TCF-1/Bcl-6 axis and suppresses the cytotoxic gene program.

bioRxiv · May 18, 2022 · PreprintImmunology

Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice

A. Zani, A. Kenney, J. Kawahara, A. C. Eddy, X.-L. Wang, M. KC, M. Lu, E. A. Hemann, J. Li, M. E. Peeples, L. Hall-Stoodley, A. Forero, C. Cai, J. Ma, J. S. Yount

This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.

bioRxiv · Dec 22, 2021 · PreprintImmunology

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

J. H. Erasmus, A. P. Khandhar, A. C. Walls, E. A. Hemann, M. A. O'Connor, P. Murapa, J. Archer, S. Leventhal, J. Fuller, T. Lewis, K. E. Draves, S. Randall, K. A. Guerriero, M. S. Duthie, D. Carter, , D. H. Fuller

bioRxiv · May 28, 2020 · PreprintImmunology