Engrafted parenchymal brain macrophages differ from host microglia in transcriptome, epigenome and response to challenge
A. Shemer, J. Grozovski, T. Leng Tay, J. Tao, A. Volaski, P. Suess, A. Ardura-Fabregat, M. Gross, J.-S. Kim, E. David, L. Chappell-Maor, L. Thielecke, C. K. Glass, K. Cornils, M. Prinz, S. Jung
This study compares transcriptomes, epigenomes, and responses to challenge between engrafted HSC-derived brain macrophages and host microglia, finding persistent molecular and functional differences.
bioRxiv · Oct 27, 2018Immunology