J.-S. Kim

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

Murine GMP- and MDP-derived classical monocytes have distinct functions and fates

This study identifies distinct functions and fates of murine classical monocytes derived from GMP and MDP, showing differential contributions to tissue macrophage populations.

Sniper2L, a high-fidelity Cas9 variant with high activity

This paper develops Sniper2L, a high-fidelity Cas9 variant with improved specificity and retained high on-target activity, and introduces a deep-learning model to predict its activity.

Mid-summer snow-free albedo across the Arctic tundra was mostly stable or increased over the past two decades

The paper analyzes mid-summer albedo changes in the Arctic tundra over two decades and finds most areas show stable or increased albedo, contrary to expectations from vegetation changes.

Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes

This study shows oocytes repair DNA damage during meiosis by recruiting the CIP2A-MDC1-TOPBP1 complex from spindle poles to chromosomes via microtubules.

Enteric glial cells favour accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

This study identifies how enteric glial cells promote the differentiation of anti-inflammatory macrophages during muscularis inflammation resolution through CCL2 and CSF1 signaling.

Decoding Imagined Musical Pitch from Human Scalp Electroencephalograms

This study decodes imagined musical pitch from human scalp EEG, achieving 35.68% accuracy using SVM and showing similar performance with DC features across different class numbers.

Rescue of transcriptional pausing in metabolic genes jumpstarts Salmonella antioxidant defenses

This study shows that Gre factors resolve transcriptional pauses in metabolic genes, enhancing Salmonella's antioxidant defenses against host phagocyte NADPH oxidase.

Production of novel biosurfactant by a new yeast species isolated from Prunus mume Sieb. et Zucc.

This paper isolates a novel yeast strain JAF-11 capable of producing a new biosurfactant with unique chemical properties and potential industrial applications.

Central role of Prominin-1 in lipid rafts during liver regeneration

This study shows PROM1 is crucial in lipid rafts for liver regeneration by recruiting GP130 and activating the IL6-GP130-STAT3 pathway.

In vivo mitochondrial matrix proteome profiling reveals RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

Endomembrane systems are reorganized by ORF3a and Membrane (M) of SARS-CoV-2

This study identifies ORF3a and M proteins of SARS-CoV-2 as reorganizing the endoplasmic reticulum and mitochondrial-associated membrane, with potential therapeutic implications.

Escherichia coli Cryptic Prophages Sense Nutrients to Control Persister Cell Resuscitation

The paper shows that cryptic prophages in E. coli regulate phosphate uptake to control persister cell resuscitation, preventing premature resuscitation in nutrient-poor conditions.

Spc1 regulates substrate selection for signal peptidase

The paper investigates the role of Spc1 in yeast, showing it shields transmembrane segments from signal peptidase cleavage, thereby influencing substrate selection.

Strain variation in Bacillus cereus biofilms and their susceptibility to extracellular matrix-degrading enzymes

This study examines strain variation in Bacillus cereus biofilms and their susceptibility to extracellular matrix-degrading enzymes, revealing distinct structural and compositional differences among strains.

The SARS-CoV-2 RNA interactome

This study identifies 109 host factors interacting with SARS-CoV-2 RNA and reveals their roles in antiviral or proviral functions through RNP capture and knockdown experiments.

Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

The paper introduces iSLET, a method to track tissue-specific secretory proteins in live mice, demonstrating its use in labeling and identifying liver-specific secreted proteomes in blood plasma.

Prominin-1-Radixin Axis controls hepatic gluconeogenesis by regulating PKA activity

The paper shows that Prom1 regulates hepatic gluconeogenesis by modulating PKA activity through its interaction with radixin.

Comparative analysis of CreER transgenic mice for the study of brain macrophages - a case study

The paper compares two CreER transgenic mouse models to assess their utility in studying brain macrophages and highlights considerations for their use.

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

This study identifies NSUN2 as a methyltransferase introducing 5-methylcytosine in mitochondrial tRNAs and shows its necessity for m5C modification but not for tRNA stability or oxidative phosphorylation in differentiated cells.

Engrafted parenchymal brain macrophages differ from host microglia in transcriptome, epigenome and response to challenge

This study compares transcriptomes, epigenomes, and responses to challenge between engrafted HSC-derived brain macrophages and host microglia, finding persistent molecular and functional differences.

CRISPR Cas9 searches for a protospacer adjacent motif by one-dimensional diffusion

This study uses smFRET to show Cas9 searches for PAM sequences via one-dimensional diffusion, competing with 3D diffusion for efficient target binding.

Single Cell Observations Show Persister Cells Wake Based on Ribosome Content

The paper uses microscopy to study persister cells in E. coli and finds that their resuscitation rate correlates with ribosome content.

Directed evolution of CRISPR-Cas9 to increase its specificity

This study evolves CRISPR-Cas9 to enhance specificity while maintaining on-target activity in human cells.

Viable But Non-Culturable Cells Are Persister Cells

This study shows that viable but non-culturable (VBNC) cells and persisters are the same dormant phenotype, as both are metabolically inactive and only persisters can resuscitate.